Microscopic confocal scanning system（SS-MCS)
Microscopic Confocal Scanning System (SS-MCS) is a confocal imaging product designed to achieve lower background noise, higher detection sensitivity, and higher image resolution. Its unique optical path structure and conversion circuits developed specifically for confocal imaging can simultaneously meet the requirements of high resolution, high detection sensitivity, low background noise, and large dynamic range. Compared to traditionally designed confocal microscopes, the images obtained with the SS-MCS confocal scanning system exhibit lower noise, darker backgrounds, brighter signals, and more detailed information, providing researchers with high-quality confocal images. The technical performance of this product is on par with imported brands, making it a high-end domestic alternative to foreign instruments.
It is a high-tech research technology that has rapidly developed in the past decade, with applications expanding into fields such as cell biology, microbiology, developmental biology, genetics, neurobiology, physiology, and pathology. It has become an essential tool for modern biological research at the microscopic level.
Product Features
1. Clear Imaging: Fully software-controlled multi-dimensional image acquisition, enabling multi-channel XY, XYZ, XYT, XYZT, and MP multi-dimensional imaging.
2. Live Observation: The SS-CSS6 confocal microscope can track the structure and physiological processes of live cells in their natural state or after being stimulated by certain factors, capturing the time-dependent changes for accurate and intuitive dynamic data, providing direct experimental data for analyzing cellular physiological and biochemical reactions.
3. Continuous Layer Scanning and Image Reconstruction: Allows continuous layer-by-layer scanning of different levels within the sample to obtain images of each level, with layer spacing as small as 0.1 microns or even smaller.
4. Multi-Label Technology: Enables the observation of different structures within cells in a single experiment, allowing research on the localization and interaction of different structural components.
5. Quantitative Information: Enables quantitative analysis of fluorescence localization in cells, providing fluorescence intensity values in two-dimensional or three-dimensional spaces within different parts of the sample, as well as changes in fluorescence intensity under various treatment conditions.
Product Advantages
1. Good Universality, Compatible with All Brands of Microscopes: The SS-CSS6 uses a standard C-type interface, requiring no additional accessories to connect with microscopes and set up a laser scanning confocal imaging system, obtaining high-quality images.
2. Laser Direct Adjustment with Ultra-Long Service Life: Uses COHERENT OBIS solid-state or semiconductor lasers. By externally adjusting the laser power and switch, the service life of the laser is extended, and after-sales costs are reduced. The laser has excellent stability, with power fluctuation of <2% over 8 hours. It is ready to use and easy to operate, capable of simultaneously supporting up to four lasers.
3. High-Sensitivity PMT: Equipped with Hamamatsu's new generation of high-performance multi-alkali PMTs, with a quantum efficiency greater than 25%. Compared to foreign previous-generation confocal products, sensitivity has improved by more than double. It can be upgraded to Gallium Arsenide Phosphide (GaAsP), further enhancing the signal-to-noise ratio of the image, as GaAsP has a quantum efficiency of up to 45%.
4. XY High-Speed Scanning Mirrors: Equipped with high-speed XY scanning mirrors, the imaging speed at 512x512 resolution can reach 4 fps. It has fast response time, high repeatability precision, low heat generation, and minimal temperature drift.
Application Directions
1. Cell Biology Research: Cytoskeleton studies, organelle observation and measurement, cell viability, proliferation, and function, apoptosis and autophagy, real-time quantitative detection of intracellular ion changes, live cell imaging, phagocytosis, endocytosis, receptor internalization, etc.
2. Neurobiology: Obtaining clear images of fine structures and morphological changes of neurons in tissue samples of specific thickness. In brain and neuroscience, the confocal microscope is used for layered scanning of neural axons, internal structures of axons, and the 3D structure of neural axons, which reveals subtle pathological changes in nerve tissues not observable under ordinary light microscopes.
3. Developmental Biology: Model organisms such as Drosophila, Caenorhabditis elegans, and zebrafish embryos, allowing detailed 3D structural and dynamic changes.
4. Oxidative Stress Detection: Detecting reactive oxygen species (ROS) in cells, studying atherosclerosis, cancer, ischemia-reperfusion injury, and neurodegenerative diseases.
